To elucidate the potential anti-androgenic effects of this mixture, we evaluated DE-71 in several in vivo assays, which are responsive to alterations in androgen activity.
While changes in nitrate concentrations in large rivers are generally not as responsive to alterations in diurnal inputs and/or watershed hydrology as small rivers, high-frequency water quality sampling would help in monitoring short-term (days to weeks) variations in nutrient concentration patterns and thus improve the accuracy of nutrient flux estimates.
Consistent with this idea, in vivo gurken signaling activity is highly responsive to alterations in Bruno expression levels [28], [29].
As described above, the majority of mitochondrial genes involved in energy production are either unchanged in muscle of the septic patients or modestly increased, and this agrees with our previous conclusions that in humans, mitochondrial related mRNAs are not highly responsive to alterations in muscle usage in humans [24], [30].
However, the fibroblasts from idiopathic pulmonary fibrosis patients remained responsive to alterations in matrix rigidity with decreased proliferation and contractile properties when plated in soft matrices.
In this and previous studies (Mishima et al., 2009), genes related to the actin cytoskeleton are highly responsive to alterations in miR-1 expression.
Nevertheless, these studies allowed us to define a core modulon of FeHm-responsive genes, numbering 74, that were responsive to alterations in FeHm levels in all three studied H. influenzae isolates.
In search of rapidly responsive molecular alterations in mammalian cells, short-term microgravity provided by parabolic flight maneuvers is an ideal instrument to elucidate initial and primary effects, without the influence and interference of secondary signal cascades.
Temporal resolution revealed sustained and transient, early and late-responsive metabolic alterations.
It remains to be tested whether miR-146a is responsive to alteration of mechanical load in addition to proinflammatory cytokine.
