In general, intentionalists hold that self-deceivers are responsible, since they intend to acquire the self-deceptive belief, usually recognizing the evidence to the contrary.
The emergence of only one QRDR mutation in E. coli in this study may be mainly responsible for the failure to acquire orbifloxacin resistance.
We therefore propose that these structural changes, in combination with a now membrane tethered TR3 are responsible for Meso-TR3 to acquire its full cytotoxic potential at the target cell membrane.
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Finally, the analogous substitution to T790M in BCR-ABL, T315I, is responsible for acquired resistance to ABL inhibitors in chronic myelogenous leukemia (CML) but has also been detected in CML patients before treatment [13].
In lung cancer, MET amplification is responsible for acquired resistance to anti-EGFR tyrosine kinase inhibitors in up to 20% of cases (Engelman et al, 2007).
The expression of mexAB-oprM, responsible for acquired resistance to fluoroquinolones is regulated by the quorum-sensing, and, therefore, is known to be growth-phase dependent [ 36, 37].
Bioinformatic analysis highlights the biological processes that might be responsible for acquired resistance to RH1.
Furthermore, Nrf2 is up-regulated in resistant cancer cells and is thought to be responsible for acquired chemoresistance.
Moreover, studies in lung cancer have shown that MET gene amplification is responsible for acquired resistance to EGFR-tyrosine kinase inhibitors (Engelman et al, 2007).
