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Although it has been known for more than three decades that osteoclasts are hyperstimulated by cytokines in myeloma, the osteoclast-activating factors (OAFs) responsible proved elusive until the late 1990s.
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However, just as in the wider economy, where the actions of the financial institutions on Wall Street brought on a global recession, the widely-held assumption that private banks and microcredit institutions would be responsible also proved to be spectacularly wrong.
Although DON-3-glucoside represents up to 46% of the total amount of DON in infected wheat and maize varieties (Berthiller et al. 2009), cloning the responsible glucosyltransferase proved difficult because of the high number of UDP-glycosyltransferase genes in the genomes of cereal plants.
The TSA would point to the airline; the airline would point to the TSA; and in the end, nobody was held responsible because nobody could be proved responsible.
But there are some limitations: travelers and the company they book their trip through are responsible for proving, if asked, that they meet the requirement.
In addition to Jacques Torres (66 Water Street), Li-Lac (40 Eighth Avenue, at Jane Street), and Kee's (80 Thompson Street), there's Verē, which bills itself as salutary and socially responsible, and proves it by adding something nutritious called a prebiotic to its Rainforest Alliance Certified line, turning out a confection that is suspiciously unsweet.
The party responsible for proving a fact had to produce a number of witnesses (usually 12) who would swear that he was telling the truth; they did not testify about the fact itself and, indeed, might have no personal knowledge concerning it.
European legislation is about to tighten the way chemicals are regulated and make chemical companies responsible for proving the environmental safety of the chemicals they produce.
Instead of requiring the user to be completely responsible for proving who they are, it puts the burden (and control) in the hands of the administrator where it makes more sense.
One way to avoid wrongful convictions would be to hold the state responsible for proving beyond a reasonable doubt that a crime was actually committed before being allowed to introduce evidence of guilt.
Under British law, she was responsible for proving that she hadn't in fact defamed him.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com