If inflation of healthy lung regions during mechanical ventilation is safe (but useless), hyperinflation-induced overdistention of nondependent lung regions may be harmful and is probably a major issue in mechanical ventilation, responsible for ventilator-induced lung injury [ 2].
The association of controlled ventilation and hyperoxia are known as key synergetic factors responsible for ventilator induced lung injury (VILI) [ 20].
Various mechanisms are responsible for the ventilation-induced release of mediators.
I got impatient with some of the stuff I saw going on about damp and mold, about who's ultimately responsible for improving the ventilation in people's houses.
On the other hand, patients receiving too much fluid may develop complications associated with fluid overload, such as tissue edema, which may be responsible for prolonged mechanical ventilation and delayed wound healing [11].
We conclude that the dead space decrease by split flow signs responsible for the reduced ventilation requirements, and would expect correspondingly less pulmonary injury.
4. If recruitment of dependent alveoli, which collapse at FRC, is responsible for redistribution of ventilation to dorso-caudal lung with increasing tidal volume, then application of PEEP should reduce this redistribution.
Hypoxic pulmonary vasoconstriction may be responsible for maintaining the ventilation-perfusion ratio during localized alveolar hypoxia.
The peripheral chemoreceptors are the dominant reflex mechanism responsible for the rise in ventilation and muscle sympathetic nerve activity (MSNA) in response to hypoxia.
