Sentence examples for responsible for relapse from inspiring English sources

This observation is also consistent with the findings of several genomic studies that indicate that clones responsible for relapse are often present at diagnosis or mutated to a resistant phenotype through intrinsic genomic instability rather than treatment exposures [15, 16].

Tumour heterogeneity and clonal evolution within a cancer patient are deemed responsible for relapse in malignancies and present challenges to the principles of targeted therapy, for which treatment modality is often decided based on the molecular pathology of the primary tumour.

CSC make up only a fraction of a percent of total tumor bulk, and due to the high plasticity of their phenotype and their ability to remain quiescent for probably many decades, they are held responsible for relapse and therapy failure [6],[7].

The cancer stem cell theory suggests that rare tumorigenic cells, resistant to conventional therapy, are responsible for relapse.

This suggests that common resistance pathways may be responsible for relapse [ 59].

In spite of treatment, patients retain the diseased cells referred to as minimal residual disease (MRD) responsible for relapse.

Although American (11 ) and African TBRF Borrelia (12 ) are now better characterized, no definitive molecular characterization of Borrelia species responsible for relapsing fever has been achieved in Israel.

Although P. vivax and P. ovale are responsible for relapses (4 ), P. malariae is sustained at low rates among sparse and mobile human populations for decades, thus facilitating transmission by mosquitoes (2 ).

Thus, a single infection with P. vivax can be responsible for a relapse or series of relapses after an apparent cure.

Another very promising, regenerative approach would involve "purging" stem cells responsible for cancer relapse directly out of the patient "by acting on their biological features", Airoldi adds.

However, a small population of tumour cells persists and is responsible for tumour relapse following treatment discontinuation, mimicking the situation found in humans5.