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Significantly the phenotype we obtained with the chaperone knockdowns is highly similar to that for GPI8, the trans-amidase responsible for addition of the GPI-anchor to VSG and other polypeptides [62], which suggests that this is the generic defect obtained when ER function in T. brucei is significantly compromised.
The enzymes responsible for addition and removal of a phosphate moiety, kinases and phosphatases, respectively, are highly abundant in nature.
POMGnT1 is responsible for addition of an N-acetylglucosamine residue in β-1,2 linkage to the first mannose residue.
NRPS are multi-modular enzymes in which each module is responsible for addition, attachment or modification of a specific amino acid onto a growing peptide chain [ 71].
Recently, we generated a mouse that does not contain any VLC-ceramides and VLC-sphingolipids (SLs) because of ablation of ceramide synthase 2 (CerS2), the enzyme responsible for addition of very-long acyl chains to the sphingoid long chain base.
3β-HSD and 5β-POR and mono-oxygenase genes are involved in the initial steps of cardenolide biosynthesis toward cardenolide genin formation, GT genes are responsible for addition of sugars to the genins, whereas CGH is involved in the degradation of primary cardiac glycosides.
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In contrast to Alan, Colleen, described the administrative responsibilities that she is also responsible for in addition to her family practice, and did not discuss patient care in much detail.
In addition, in the late 1980s, the glycosyltransferase responsible for the addition of GlcNAc to proteins was found to be orientated with its active site in the cytoplasm, and the first proteins modified with O-GlcNAc were described [ 6].
Although the Romans made no extraordinary metallurgical discoveries, they were responsible for, in addition to the establishment of the brass industry, contributing toward improved organization and efficient administration in mining.
O-GlcNAc transferase (OGT) and neutral β-N-acetylglucosaminidase are responsible for the addition and removal of O-GlcNAc [9].
In the gonococcus, the gene rfaF is responsible for the addition of the second heptose onto heptose 1 [18].
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