These observations suggested that NaCl played an important role in exerting enzyme thermal stability while CaCl2 was only responsible for activating enzyme activity.
To confirm Tyr71 as the phosphorylation site responsible for activating the enzyme, the dehydrogenase activity of Ugd and UgdY71F was measured with or without prior incubation with Wzccyto and ATP (Fig. 2B).
Finally, the components of F. tularensis that are responsible for activating innate immune responses in the host are just beginning to be identified [31], [66].
Some works focus only on modeling the innate IS [ 38– 40], which is responsible for activating the adaptive response.
Subset of antigens that is mainly responsible for activating the immune response can be used in adjunction with BCG or for booster doses to enhance immune response.
In support of this notion, ARF, which is responsible for activating p53 in response to oncogenic stresses, also suppresses induced pluripotency [ 124– 124].
ABA stimulates expression of transcriptional activators such as ABF/AREB transcription factors, which are responsible for activating expression of downstream stress-responsive genes in ABA-dependent stress signalling (Zhu 2002; Yamaguchi-Shinozaki and Shinozaki 2006).
These data therefore suggest that Net1 is the major GEF responsible for activating nuclear RhoA in response to a DNA damage stimulus.
One target of particular interest is hIKK-2, a serine-threonine protein kinase belonging to the IKK complex that is the primary component responsible for activating NF-κB in response to various inflammatory stimuli.
According to several authors, DCs are one of the most important cells responsible for activating an efficient immune response, and these cells have been used as tumor treatments in immunotherapy models [39], [40].
This demonstrates that fungal cell wall polysaccharides are unlikely to be responsible for activating either the proinflammatory response or the filamentation-associated discriminatory mechanism.
