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Therefore, we hypothesized that specific subcellular localization of certain members of cell cycle-regulating machinery may be responsible for absence of the expected link.
We speculate that the substantially lower serum NMO-IgG concentration in the study of Kitic et al. [ 18] was responsible for absence of robust NMO pathology.
However, we do not believe that low levels of the huRANKL MAb are responsible for absence of an effect on osteoclast numbers, since a lower dose of huRANKL MAb (3 mg/kg) inhibited the action of high-dose human RANKL (0.5 mg/kg) in the circulation for four days.
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Because we did not find evidence for chromosomal lesions being responsible for an absence of IFNα response, the question on the mechanisms underlying IFNα resistance remains open.
These results confirm that overexpression of CCM/ICAP-1 proteins is responsible for the absence of morphological response of EA.hy926 most likely by preventing shear-stress-induced β1 integrin activation.
Other mutations in genes encoding proteins that act downstream of EGFR, such as KRAS, BRAF, and PIK3CA, may be responsible for the absence of treatment response in such cases.
Nicholas D. Kristof and Sheryl Sandberg, the chief operating officer of Facebook, suggest that women are partly responsible for their absence in the executive suite in all professions.
That system can be activated by stress or shock and is probably responsible for the absence of pain associated with a severe injury.
"We're proud of our relationship with C.I.A. and its training," he said, saying it was partly responsible for the absence of casualties from a terror attack in New York in the years since Sept. 11 and the anthrax attacks.
A second theory holds that geography was responsible for the absence of a strong aristocracy that is, that the poorness of the soil prevented economic expansion through the creation of large estates.
Prosecutors have said the three men were responsible for the absence of a large section of the standpipe, which prevented the firefighters from getting water on the fire immediately and, they say, led to the deaths.
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