When the client or your boss asks, make sure he or she knows who is responsible for copy writing.
Next, we analyzed expression levels of DNMT1, the primary enzyme responsible for copying methylation patterns after DNA replication [ 29].
It is referred to as a "maintenance" methyltransferase and is the primary enzyme responsible for copying the methylation patterns after DNA replication.
DNA polymerases (pols) 1 are essential components of replicases, which are multiprotein complexes responsible for copying genomes of all organisms with high fidelity (for reviews, see refs (1− 3)).
However, the proteins that are responsible for copying the DNA cannot reach the very end of the DNA strand, causing the chromosomes to progressively shorten.
Among several possible models, it has been proposed that Pol ε is primarily responsible for copying the leading strand DNA template and Pol δ is responsible for lagging strand replication [ 13].
A third enzyme, Dnmt1, is the 'maintenance' enzyme responsible for copying DNA methylation onto the nascent DNA strand at 'hemimethylated' sites that have arisen from symmetrically methylated CpG dinucleotides during DNA replication.
These findings suggest that δEF1 constitutively interacts with DNMT1 at hemi-methylated DNA of the E-cadherin promoter region, where it is likely to be responsible for copying and maintaining DNA methylation, resulting in severe repression of E-cadherin expression in Hs578T cells.
When Lasker started in advertising, agencies were chiefly responsible for taking copy that clients had already prepared and placing it in various publications.
Plotting this raw data as a histogram shows that DNA cohort origin is clearly responsible for systematic copy number calling bias in QPCR between "poor quality" DNA from the Portuguese and Ghanaian cohorts and "good quality" DNA from the UK, Danish and Czech cohorts (Figure 4a) but had no effect on copy number calling for the two PRT-based methods (Figure 4b and 4c) but.
