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Accordingly, we have initiated transcriptome profiling studies of Ar. subalbatus in relation to anti-filarial worm immune responses to clarify molecular components involved in B. malayi refractoriness.
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A small update has added to Reed's response to clarify a point of unclear syntax.
Response : To clarify, we have focused on VP35 not VP30.
We also measured BCR ABL transcripts as a biomarker for imatinib response, to clarify its effect even when the disease was in CR.
This study has identified genes that can play a critical role in programming the innate immune response, helping to clarify the mechanisms leading to protection or damage during inflammatory conditions in the CNS.
Author's response: Just to clarify - we see the public goods hypothesis as providing not only a metaphor (clearly the Tree of Life provided a diagram/metaphor that could be used to describe evolving cellular life), but we see the Public Goods hypothesis as a description of the process of evolution - genes as goods that can be utilized, exchanged, protected, etc.
We investigated the effects of ARE on inflammatory responses to further clarify the molecular mechanisms whereby ARE restricts the development of atherosclerotic lesions.
Because Smad7 can abrogate both Smad2- and Smad3-dependent responses, we sought to clarify the specific role of cellular Smad3 in PPAR-γ suppression using mouse fibroblasts deficient in Smad3 [30].
Interviewers listened for completeness and consistency in responses, asking participants to clarify and/or further explain their answers.
Additional research on the effects of perinatal nutrition and growth patterns on glucose metabolism and autoimmune responses is needed to clarify the etiologic pathways.
An exact definition of response is difficult to clarify, but has generally been considered as any beneficial response of the tumour to a particular therapy.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com