We will discuss the humoral responses targeting MPER in detail below.
Population studies of HIV-1-infected individuals suggest that CD8+ CTL responses targeting epitopes that take the greatest toll on virus replication are instrumental in immune control.
Two CD8+ T cell responses targeting the SARS-CoV membrane (M) and nucleocapsid (N) proteins were characterized by determining their HLA restriction and minimal T cell epitope regions.
Potent autologous tier 2 neutralizing responses targeting basic residues in strand C of the V2 region, which forms the core epitope for V2-apex bnAbs, were observed.
CD4+CD25high regulatory T cells play an important role in suppression of a wide range of immune responses targeting various microbes, intracellular parasites, allergens, allo-antigens, and tumors [1 6].
We carried out a rapid assessment among the female regular sex partners of drug users/injecting drug users recruited from Bangladesh, Bhutan, India, Nepal and Sri Lanka with the objective of designing appropriate responses targeting them.
Subsequent investigations revealed a role for both humoral and cellular immune responses targeting the sporozoite and the infected hepatocyte, respectively3.
We observed no difference in the magnitudes of responses targeting HLA-B*35 specific epitopes in either HLA-B*35 -Px+ or -Py+ individuals.
Although Pol, Vpr and Rev epitopes are presented early as well, responses targeting those epitopes seem to be less efficient in controlling the viral replication.
In contrast, the level of polyfunctionality did not differ among HIV-1-specific CD8+ T-cell responses targeting other viral proteins.
Finally, eight newly identified CD4+ T cell epitopes will provide new reagents for tracking and analyzing the immune responses targeting C. burnetii.
