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This reduction in cone responses progressed with age, with 12 month-old Guca1a+/COD3 mice retaining 42% of the photopic ERG b-wave amplitude of their wild-type littermates (Figure 3a, c).
Most interestingly, none of the 19 tumours that had shown objective responses progressed during the observation time of this study.
Although the change in QOLI at follow-up was moderate (d = 0.48) and scores at follow-up were still very low (mean = 0.43, SD = 1.73), responses progressed into the 'satisfied' range of QOLI.
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"There is no plan," one politician took to saying as the response progressed last summer.
By focusing on these early time points, in which tumor outgrowth and subsequent regression occurred, we hoped to better understand not only how effector T cell function differed within the tumor mass relative to distal lymphoid organs, but also to identify changes that occurred in each site as the anti-tumor response progressed.
The one patient who achieved an objective or partial response progressed by cycle 5.
Interestingly, five of the six patients evaluable for treatment response progressed after starting dexamethasone for prevention of the symptoms.
By comparison, 3 of 61 patients with complete metabolic response progressed, with no deaths in this group.
Unfortunately samples were not available to investigate how the response progressed later than 30 hours following infection.
All three patients (2 MS, 1 SS-m) who obtained a partial response progressed after 5, 6 and 8 months from the end of initial therapy.
Recently a novel ALK F1174V mutation has been found in an ALK-positive NSCLC patient who, after a first partial response, progressed on crizotinib 36.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com