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Although peptide fragments can bind cell surface MHC molecules directly and elicit T cell immune responses, presentation of native Ag by APCs to CD4+ T cells in vivo usually requires processing, which involves proteolytic degradation of protein within APCs and association of peptide cleavage products with MHC II molecules [19], [20].
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In particular, differences in 43 probe sets associated with GO groups - immune response, defence response, antigen presentation and response to stress were identified.
Interestingly, these 43 probe sets are associated with GO groups for immune response, defence response, antigen presentation and response to stress.
This agrees with our findings that animals with higher IL10 levels presented a decreased expression of biological functions related to cellular immune response, antigen presentation and inflammatory response.
For instance, the fusiform gyrus, an area hemodynamically active in our study, shows enhanced responses upon presentation of visual stimuli (faces) depicting danger [36].
The major histocompatibility complex (MHC) of vertebrates is a highly polymorphic region that controls immune responses through presentation of pathogen-derived peptides to T cells [1].
Furthermore, the existing GO annotation implicates many genes in autoimmune responses, antigen presentation and other immunological functions.
Impulsive individuals show a higher rate of failure to inhibit responses following presentation of the stop signal (Logan et al., 1997).
For example, only few neurons show increased responses upon presentation of stimuli that strongly engage normalization mechanisms, such as surround/mask stimuli (Walker et al., 2000).
Alteration of the expression of genes involved in immune response, antigen presentation, apoptosis, and acute phase response have been also reported in a similar study [ 52].
Licking at a steel tube providing 2.5 µl of water reinforcement in response to presentation of the S+ served as the operant response.
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