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Although a reproducible experimental model that is easy to establish, endotoxaemia is not a perfect model of sepsis, with differing cytokine kinetic responses, duration of sepsis and time to death [20].
Secondary end points included objective response rate (ORR) (complete responses plus partial responses), duration of response, and overall survival (OS).
The rate of complete responses, duration of overall objective response, progression-free survival (PFS), and overall survival were the secondary endpoints.
There was one complete response (duration 8 months), five partial responses (duration 2 7 months), 10 patients with stable disease (duration 1 5 months), and 11 patients with progressive disease.
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Most series report response rates of 60%to7070% with a median response duration of approximately 10 months.
The results confirmed the superiority of VRD in increasing PFS, response duration, and OS34.
Response duration was calculated using the Kaplan Meier method and compared by the log-rank test.
Response duration was longer in the thalidomide/prednisone/danazol cohort (HR 2.18 (1.18–5.42); P = 0.019).
The median response duration was 8 months (range, 3 51+ months).
Response duration was defined as the interval from anemia response to loss of response, change of therapy, or death.
Our data suggest adding danazol to thalidomide/prednisone improves response rates, prolongs response duration in persons with PMF and anemia with and without RBC transfusion dependence.
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