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Although alum is effective in boosting antibody responses, achieving these responses requires repeated administration and tend to be biased towards T helper (TH) 2, rather than TH1, immunity [4].
Significantly, however, we observed that the benefit in OS was clearly related to the number of outcomes in which a response to therapy was observed, such that the greatest benefit was seen in those patients who had multiple responses achieving 'disease control' in two or three of clinical, biochemical and radiological outcomes.
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Both companies said the responses achieved their goals.
The results obtained by (Zhou 1992) are compared with the responses achieved by BEM to validate the numerical BEM formulation.
In these applications, experimental and analytical results available in the literature are compared against the responses achieved by the BEM.
The 17 full responses achieved RMSE values spanning a large range from 0.942 to 3.020 log S units.
The forward responses were calculated on both the TE and TM modes and the results were compared with the original responses achieved through inversions.
The sample was systematic and randomized across rural and urban regions, with a total of 1445 valid responses achieved.
In this adjusted set of results, the 17 full responses achieved RMSE values spanning a smaller range from 0.942 to 2.313 log S units.
It is worth mentioning that the responses achieved by the implemented BEM approach presents good agreement to references adopted in literature and numerical stability as well.
The combination was clinically active, with complete and partial responses achieved in heavily pretreated patients.
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