Although endothelin-1 can elicit prolonged physiologic responses, accumulating evidence suggests that rapid desensitization affects the primary G protein-coupled receptors mediating these responses, the endothelin A and B receptors (ETA-R and ETB-R).
Existing studies indicate that the retrograde response accumulates overall a cell's lifespan, which compensates for mitochondrial dysfunction as mitochondrial quality control (Owusu-Ansah et al., 2013, Raimundo, 2014).
Neutrophils typify the early inflammatory response, accumulating at sites of infection and tissue injury [ 1, 2].
There's also the inexorable decline over time, my rate dropping in response to accumulated responsibilities, children to care for, piled-up magazines competing for my attention.
To model the temporal extent of the interactions, the detection responses are accumulated over time to generate spatiotemporal localization tubes.
The CS responses were accumulated for each learning trial in bins with widths of 100 ms, and then were converted to the probability of a CS in each bin.
Initially, 20 patients were randomised equally to each treatment arm; thereafter, as response information accumulated, successive patients were randomised in favour of the treatment that, on average, elicits a higher response rate.
As expected, NPC1 mutant cells displayed an inappropriate homeostatic response to accumulated intracellular cholesterol.
The four variables were found to be significant in altering the response variable (accumulated loss of mass).
However, during the first response, charges accumulated at the interface created large force at the second and later pulses.
