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18 proteins are assigned to homeostasis and blood coagulation (wound healing phase I), 35 proteins are assigned to inflammation or defense response (wound healing phase II), and 19 are related to proteolysis and remodeling (wound healing phase III and IV).
The mechanisms by which macrophages control the inflammatory response, wound healing, biomaterial-interactions, and tissue regeneration appear to be related to their activation/differentiation states.
Selectins are involved in processes of immune response, wound repair, inflammation, and hemostasis.
Because of a lack of clinical response, wound swabs or biopsy specimens were obtained.
This phenotype might influence the immune response, wound healing, metastasis or invasive growth of cancer cells in vivo [ 14, 15].
Indeed, OPN has a role in many different physiological settings, including immune response, wound repair, vascular homeostasis, bone remodeling, and renal functions [ 121].
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The syndecans are the major family of transmembrane proteoglycans in animals and are known for multiple roles in cell interactions and growth factor signalling during development, inflammatory response, wound-repair and tumorigenesis.
The genes involved in wounding response and wound healing were enriched among both the up- and down-regulated transcripts, dependent on the tissue.
Thus, the lack of syndecan-1 or -4 in mice results in impaired inflammatory responses, wound-healing, and angiogenesis [ 10, 21, 35].
If this feedback loop has a gain of less than 1, it would allow a faster response to wounds and faster wound healing.
(C ) Maximum single-cell (dots) Ca2+ response to wound with respect to distance away from the wound (pink).
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