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Evaluation of complications and clinical response were based on endoscopic evaluation one month after the last session and at less one year after the end of treatment.
Therefore many of our inferences between time and titer levels, particularly during the early rise of antibody response, were based on small numbers of data-points at each week time interval.
Quantitative expressions of the intrathecal immune response were based on calculation of the CSF/serum quotients (Q) of specific antiviral IgG antibodies (IgG[spec]) and total IgG (IgGtotal): QIgG[spec] = IgGspec[CSF]/IgGspec[serum], and QIgG[total] = IgGtotal[CSF]/IgGtotal[serum]).
Effect size estimates for MPH response were based on Cohen f.
The diagnostic criteria of MM, ISS stage, and the international myeloma working group (IMWG) response were based on the precedent review [ 9].
Definitions of clinical remission and response were based on CDAI scores from baseline to weeks 2, 4, 6, 8 and 12 visits.
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