Clopidogrel response variability and non-responsiveness are established concepts.
To address the various limitations of thienopyridine therapy (including response variability and non-responsiveness) a novel drug, AZD6140, is under clinical development.
Subsequently, distributions of variables were examined to assess response variability and missing data.
Variable active metabolite generation is the primary explanation for clopidogrel response variability and non-responsivenes.
Basalyga, G. & Salinas, E. When response variability increases neural network robustness to synaptic noise.
Clopidogrel linking evaluation of platelet response variability to mechanism of action.
Stahlman, W., David, W., Young, M. E. & Blaisdell, A. P. Response variability in pigeons in a Pavlovian task.
Neural responses are typically characterized by computing the mean firing rate, but response variability can exist across trials.
Changes in FEF response variability, as measured by the Fano factor (FF), showed clear dissociations from changes in FR.
Importantly, response variability predicted reaction time whether or not there were any accompanying changes in mean firing rate.
These results demonstrate that response variability of area V4 neurons, like mean response rate, provides a signature of saccade preparation.
