Crucially, there is significant inter- and intra-individual variability in response to, and tolerance of, chemotherapy treatments.
Significant inter-individual variation exists in clinical response to and tolerance of antidepressant medication.
Here, we investigate the potential role of five pharmacokinetic genes on the response to and tolerance of citalopram using a large clinical sample of depressed patients who were enrolled in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study [15].
The finding that the glucose response to glucose tolerance test is much higher in the high-fat fed controls, also suggests that these have impaired insulin secretion, when challenged with glucose, and that EPO over-expression counteracts this impairment.
Some studies (16) demonstrated that individuals diagnosed with depression showed greater insulin and glucose response to glucose tolerance tests.
Plant response to salt tolerance is influenced by various physiological mechanisms, which are likely to be controlled by multiple genes across different environments [ 79].
As one of important transcription factor family, the plant bZIP transcription factors play pivotal roles in developmental processes and multiple stresses in response to environmental tolerance.
The role of the protein in the response to acidity tolerance was established in Bacillus subtilis, Brevibacterium flavum, Listeria monocytogenes and Staphylococcus aureus[ 43- 45].
Thus, expression of PD-L1 on activated monocytes/macrophages may represent a novel mechanism that links the proinflammatory response to immune tolerance in the tumor milieu [ 24].
Development of tolerance may engender costs leading to trade-offs in other fitness-related life-history traits, as observed for East African populations of An. gambiae in response to increased tolerance to heavy metals [ 88].
