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The observed B cell changes were associated with a functional alteration of the humoral response to tetanus toxoid.
The T cell proliferative response to tetanus toxoid was inhibited when the antigen was presented by autologus monocytes transfected with Fas ligand.
Among the toddlers, the antibody response to tetanus remained high, but the response to diphtheria toxins was reduced by 24.4percentt for each doubling of the measured PCB exposure level.
As a result of repeated childhood vaccinations, a robust T cell-specific response to tetanus antigen is expected in healthy children and adolescents.
In vitro T-cell activity in response to tetanus toxoid protein was assessed.
Activation of Fyn, AKT, and MAPK in response to tetanus stimulation was defective in Irs2−/− mice.
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Moreover, these particles were very efficient in improving the nasal absorption of insulin as well as the local and systemic immune responses to tetanus toxoid, following intranasal administration.
Finally, we used an optimized cryopreservation protocol with different media additives to determine if functional T cell responses to tetanus toxoid could be preserved.
The immune responses to tetanus and PRP antigens (GMCs) were higher in infants who received the study vaccine than in those who received the control vaccine (Figure 2).
Proliferative responses to tetanus toxoid were significantly lower when comparing RA PBMC with healthy control PBMC.
CDP7657 also inhibited primary and secondary immune responses to tetanus toxoid in a nonhuman primate mode [ 200].
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