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Except.... "Except" is the word on which "Private Life" could be said to turn, unless it's the word "alas," that bitterly exhaled emotional response to reversals and defeated expectations.
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This contrast revealed a relative deactivation in vmPFC in response to reversal cues (Fig. 3 A).
We observed a degree of reciprocity in response to reversal cues, with decreases in vmPFC responses concurrent with increases in caudate responses.
We next tested for the effects of drug (levodopa/placebo) and reversal type (salient/null blocks) on this response to reversal cues, (Treversal − 1− Treversal), extracting contrast estimates from a 4-mm sphere centered on the peak coordinate in vmPFC and submitting these to a 2 × 2 ANOVA (reversal type × drug).
Steady-state VEPs were recorded in response to reversal (4 Hz) of a horizontal sinusoidal grating (spatial frequency, 0.07 cycles/deg; contrast 10%, 20 %, 30 %, 90, generated by computer on a display (Sony; 40 × 30 cm; mean luminance 15 cd/m) by a VSG card (Cambridge Research Systems).
However, it is also important to note that prefrontal responses to reversals in the normative (placebo) condition were most marked following salient loss outcomes in a way not seen within striatal regions.
Paired t-tests were used to produce SPMs testing for drug effects on responses to reversal cues.
Data from one subject had to be excluded due to a very high overall accuracy in the trial after reversal (>95%) thereby preventing our ability to contrast correct and incorrect responses to reversal trials.
Accordingly, posterior Superior Parietal Lobule, anterior Prefrontal and Dorsolateral Prefrontal cortices exhibited differential BOLD signal changes in response to perceptual reversals under working memory load.
(Fig. 3E) presents peristimulus-time histograms of a Y-cell in response to contrast reversal sinusoidal gratings (spatial frequency 0.07 c/d, contrast 100%).
A similar response to the reversal in the cortex and hippocampus may reflect general arousal or response enhancement in the thalamus or brainstem.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com