Sentence examples for response to mutations from inspiring English sources

Similarly, response to mutations (using mutation-accumulation experiments [ 6]) identified TATA boxes and trans-mutational target sizes (number of proteins influencing the expression of a focal gene) as determinants of neutral variability.

The rapid changes in CenH3 could represent the host's response to mutations in the centromeres.

One reason for design failures is conformational plasticity, as proteins frequently change their conformation in response to mutations.

Consistent with a unique origin for pediatric low-grade glioma, third ventricle, but not lateral ventricle, NSCs hyperproliferate in response to mutations characteristic of childhood glioma.

Naively, one would expect properties that appear to depend principally on the core to be similar to TNfn3, for example, the response to mutations, folding kinetics and side-chain dynamics, while properties apparently determined by differences in the surface and loops, such as backbone dynamics, would be more like FNfn10.

The precise spatiotemporal expression of Shh in the limb bud is perturbed in response to mutations within the ZRS.

Similarly, e-h represents interactions of least active compound within binding pocket of wild type and mutated proteins to show how the compound 46 lost its interactions and activity due to conformational change occurred in response to mutation.

By contrast with the native state, however, the intermediate ensemble is flexible enough to change in response to mutation, its structural properties being tailored by residues in the sequence encompassing the native helix III.

Utilizing this global analysis approach, the perturbations on the global stability in response to mutation can be partitioned between the monomer folding and association steps, and the effects of mutation on the populations of the folded and unfolded monomeric states can be determined.

A crucial point of this paper is that the response to mutation of genes in the topmost layer has highly unpredictable impact on the genes lower in the causal cascade and that the effect of mutation can disappear in the cascade of reactions.

We used the physical property distance to predict which amino acids are most variable in response to mutation bias.