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Having validated the model, we could test the response to modification of treatment, i.e., to the change in dose size or administration schedule.
Activation of primary nitrogen assimilation in response to modification of the nitrogen source has been demonstrated in placental tissues cultured in vitro [ 8].
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While femoral artery occlusion in a mouse is a simple model for limb ischemia compared to the slowly progressive disease in humans, the results of this study support the value of radiolabeled RGD as a non-invasive tool to follow the angiogenic response to modifications in factors affecting the angiogenic response to tissue hypoxia.
This suggests that particular mechanisms are involved in raising mitosis rates in response to modifications in serotonin activity.
These properties are often mentioned in relation to secondary structure changes in response to modifications occurring in vivo, although their structural impact in physiological environments is less clear.
Huge variability of tidal volume delivery with some devices in response to modifications in respiratory mechanics and FIO2 should make clinicians question their use in the clinical setting.
Longitudinal and quasi-experimental studies that examine changes in sedentary behaviour, physical activity, and diet in response to modifications to the neighbourhood and home physical environments are needed to provide stronger temporal evidence.
For example, the density of synaptic inputs to hypothalamic nuclei and specific neuronal populations involved in metabolic control are altered in response to modifications in leptin signaling or increased body weight (bw) during early development (3, 5– 7).
In conclusion, we found that in postoperative patients undergoing assisted spontaneous breathing diaphragm thickening was a good indicator of changes of inspiratory muscle effort in response to modifications of the PS level.
In this physiologic, clinical pilot study we found that diaphragm excursion was not correlated to any index of muscle effort under varying levels of muscle loading; we also found that diaphragm thickening was a good indicator of changes of inspiratory muscle effort in response to modifications of the support level.
Protein physicochemical properties must undergo complex changes during evolution, as a response to modifications in the organism environment, the result of the proteins taking up new roles or because of the need to cope with the evolution of molecular interacting partners.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com