Cogdill, A. P., Andrews, M. C. & Wargo, J. A. Hallmarks of response to immune checkpoint blockade.
We next explored the qualitative nature of isoform changes in response to immune or infectious challenges.
The dance of the perivascular and endothelial cells: mechanisms of brain response to immune signaling.
Miao, D. et al. Genomic correlates of response to immune checkpoint therapies in clear cell renal cell carcinoma.
Hong, X. et al. Molecular signatures of circulating melanoma cells for monitoring early response to immune checkpoint therapy.
Kinugasa, T., Sakaguchi, T., Gu, X. & Reinecker, H. C. Claudins regulate the intestinal barrier in response to immune mediators.
The increase in non-coding isoforms detected in response to immune stimulation could also reflect noisy splicing (i.e., splicing leading to non-functional transcripts)22,23,24.
Laurent, L. et al. Fcgamma receptor profile of monocytes and macrophages from rheumatoid arthritis patients and their response to immune complexes formed with autoantibodies to citrullinated proteins.
Intratumoral accumulation of Batf3-dependent DCs is required for development of anti-tumour CD8+ T cells13 and for response to immune checkpoint inhibitors23.
Increased mutation burden and defective DNA repair are associated with response to immune checkpoint inhibitors in several other cancer types.
They also had to grapple with the fact that Neisseria, like many pathogens, has coat materials that shift in response to immune pressures, making it necessary to target multiple coat elements simultaneously.
