It also remains to be seen why an organisation for directional tuning accounts for just a portion of the variability of supragranular neuronal responses
Responses to deflections in all eight directions, starting from all corners, were sampled.
Whilst there are some tip-link like links present between the stereocilia at the early stages of development that may mediate transduction events in the av3J/av3J and v2J/v2J mutants, it is hard to see how these would mediate excitatory responses to deflections that are normally inhibitory (i.e., away from the kinocilium).
These differences in response to whisker deflection could, at least in part, be due to the pattern of TC-axonal arborizations in the cortex, in addition to the wider dendritic spread of infragranular pyramids.
We believe that calling aJO neurons necessary does not imply that they are the only sensory neurons on the antennae that induce grooming in response to antennal deflections.
The only noticeable functional defect in pre-hearing OHCs of Pls1 KO was a small but significant slowing of the fast component of adaptation but an overall greater extent of adaptation of the MET current in response to mechanical deflections of their bundle.
The estimated AP budget of a cortical column in response to a principal whisker deflection is 3155 and 4441 for the 50 and 100 ms post-stimulus interval, respectively (Table 3).
The shift in response probability was also observed at lower stimulus intensities, where the small group of control cells that maintained their response to very low-intensity deflections (0.06°) failed to respond on 84% of trials.
Under the assumption of rigidity, the molds are expected to undergo negligible deflection in response to the large internal forces that originate from the cumulative effect of high fluid (polymer resin) pressure and the compression of the fibrous reinforcement.
