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Author's response: This discussion has been expanded and made more specific.
Authors' response: This discussion on the long-term persistence of domesticated sequences is indeed interesting, and is now mentioned in the manuscript.
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It is out of the scope of this paper to provide a proper response to this discussion.
In response to this discussion, Ian Jarvie (1966) proposed as important questions for a philosophy of technology an inquiry into the epistemological status of technological statements and the way technological statements are to be demarcated from scientific statements.
In response, this e-discussion was organised to bring together diverse experts and practitioners working in this area.
Authors' response: The discussion of the HGT rates was perhaps too brief in the original version.
During this discussion, dynamic response of tumour cells to different rates of drug dosage has been observed.
We extended this discussion, also in response to point #1 in the editor's letter.
The instructor then chooses the response after discussion (response to Q1 ad ).
The manuscript illustrates variability in response with discussion of some idealized cases.
It's never meant to be decisive or definitive -- as stated in the manifesto -- but it's certainly meant to generate response and discussion.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com