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Author response: The definition of the trunk is included in the revised background section (4 th paragraph).
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The basic variants of the response spectrum method provide the peak value of each distinct response, allowing the definition of a parallelepiped envelope for the response vectors: this envelope is conservative since the peaks of distinct responses, in general, do not occur simultaneously.
Only 8±1%1% (mean ± range; right side Figure 4A, C/I category) changed their answer to an incorrect response for the definition of a secondary article.
The 'step-by-step' approach starts with a concise model definition and progresses via the constant input response and the definition of an appropriate cost (defining optimality) towards a dynamic optimal solution.
The findings of my study indicate that the more college courses one has taken, the more likely a correct response to the definition of evolution and that biology majors were more likely to respond correctly than non-biology majors.
[ 60] The use of ambiguous terms such as "physical activity," "moderate intensity" and "leisure time" may also affect a person's response, since the definition of these terms may differ between respondents and investigators.
Responses to the definition of evolution (Question 5) indicated some general knowledge of evolution.
The questionnaire used in this study was designed for participants to write qualitative responses regarding the definition of success and the factors affecting their learning success and failure.
Authors' response: We removed the definition of the EC nomenclature but we think that it is important to keep a description of previous analysis reviews on orphan enzymes in the introduction.
In turn, dynamic cytoskeleton turnover controls a wide range of related biological responses, ranging from the definition of cell shape to the promotion of cell migration, cell adhesion and cell spreading [4], [5].
Authors' response: For the definitions of global and local orphans, we use the same as the ones of Orth et al. 2010.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com