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Response termination shown as black crosses.
This activation-induced cell death was implicated in the control of immune cell homeostasis and immune response termination.
In these neurons, increase in the concentration of RGS protein (RGS9) resulted in acceleration of the response termination kinetics (Krispel et al., 2006; Burns and Pugh, 2009).
In this context, CD95-induced apoptosis plays an essential role in the maintenance of immune homeostasis and tolerance and in immune response termination.
Here, we report the first example of a viral protein modulating NF-κB signalling/activity in the nucleus by mimicking a physiological regulatory pathway of NF-κB response termination.
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The researchers demonstrated that metacontrast-masked unconscious no-go signals increased reaction times (RTs) and led to higher percentages of response terminations.
To illustrate this functional versatility, we present three specific examples: the SAP, Cbl and SOCS families of SH2-containing proteins, which play key roles in immune responses, termination of PTK signaling, and cytokine responses.
The phenomenon of anode break excitation (whereby a neuron fires an action potential in response to termination of a hyperpolarising current) can underlie a natural anti-phase rhythm, and is best understood in terms of the phase plane shown in Fig. 2.
The first step in the fourth phase, response, is termination of the release followed by preventing the spread of contamination and reducing exposure.
Interestingly, facial touch-induced inhibition in the primary auditory cortex and off-responses after termination of touch were twofold stronger than responses to vocalizations.
Although acute innate pathway inflammatory responses promote termination of infection and wound healing, chronic activation of this pathway can lead to tissue damage and fibrosis and contribute to various disease states such as atherosclerosis, arthritis, inflammatory bowel disease and even cancer [1], [2], [3].
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