As most of these products are proinflammatory cytokines and chemokines, synthesis and secretion of these products would cause inflammatory response, sensitize the neighboring cells as well as causing cell death.
Interestingly, these authors also observed that S. cerevisiae Δ sod1 and Δ yap1 were hypersensitive to exogenous gliotoxin, suggesting that a deficient oxidative stress response sensitizes this organism to gliotoxin.
Secretion of interleukin-17 (IL-17) by regulatory T helper (Th-17) cells is a critical paracrine signalling step in the inflammatory response to sensitizing antigens and mice lacking IL-17 show a blunted CHS response similar to that seen in Df11(1)/+ mice (Nakae et al, 2002).
On the one hand, the rat thalamus exhibited long-lasting hyperexcitability to cephalic and extracephalic skin stimuli in response to sensitizing inflammatory soup, and patients undergoing migraine experienced acute thalamic activation during the fMRI in response to extracephalic brush and heat stimuli, on the other hand [42].
This hyperemic response was previously shown to occur primarily through capsaicin-sensitive afferent neurons [ 30], yet endogenous PGs contribute to this response by sensitizing these afferent neurons through the activation of EP1 receptors [ 29].
It is believed that 5-HT may provoke a peripheral dopamine release [32] that can facilitate a pain response by sensitizing tetrodotoxin (TTX -resistant Na+ channels [29].
We accordingly observed that treating mice with capsaicin (1 mM) on one foot that they subsequently withdraw the treated foot from heat faster than the untreated foot: the response is sensitized (Fig. 1A).
We have previously demonstrated that the bioflavonoid quercetin (Qct) promoted a p53-mediated response and sensitized melanoma to DTIC.
Most individuals who get into contact with proteins capable of inducing an IgE response get sensitized and produce low amounts of allergen-specific IgE antibodies, which are detectable in serum 23.
From data analysis, a biomarker signature of 200 transcripts was identified, which completely separated the response induced by sensitizing chemicals vs. non-sensitizing chemicals and the predictive power of the signature was illustrated, using ROC curves.
