Suggestions(1)
Exact(4)
Inadequate nutritional intake and altered response of aging muscles to anabolic stimuli from nutrients contribute to the development of sarcopenia.
By contrast, interfering with RIG-I in replicative senescence cells can reduce the inflammation response of aging and slow the cell aging process.
We next asked if blocking AcCoA synthesis through Ach1p, which transfers CoA from short-chain Acyl-CoAs to acetate generating AcCoA (Fleck and Brock, 2009), would also affect the autophagic response of aging cells.
Similarly, deletion of SCH9, which has been suggested to act in parallel to TORC1 as an autophagy suppressor (Yorimitsu et al., 2007) as well as in the same pathway with TORC1 during lifespan regulation (Wei et al., 2009), transiently amplified the autophagic response of aging wild-type but again failed to reinduce autophagy of aging ach1 cells.
Similar(56)
The results illustrate the capabilities of the coupled oxidative aging-viscoelastic constitutive relationship to predict the viscoelastic response of aged asphalt concrete materials.
Nonetheless, they indicate that, in addition to the impact of B cell compartment (e.g. follicular to MZ/B1 skewing), 'defective' T cell help may contribute to the poor quality of the humoral response of aged individuals.
It was found that the precipitation kinetics and age-hardening response of artificial aging at temperatures below 210 °C are lowered by prior natural aging but enhanced above this temperature.
In summary, these considerations prompt the conclusion that the observed alterations of DNA repair capacity reflect a diverse response of age-associated increases in DNA damage and not a cause thereof.
In contrast, 37 age downregulated probe sets (1,3%, cluster 12) and 135 upregulated probe sets (4,9%, cluster 1) were identified in all conditions and thus represent a core response of the aging process.
This, too, could represent an immune response to aging elastic tissue of the joint capsule with the synovitis being secondary.
Reduced innate and adaptive immune responses are a hallmark of aging.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.
Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com