The responses appear to be dependent on the development of complete donor lymphoid chimerism, and responses may be delayed.
9.36pm BST 77 min: "Is it a good or bad career move to put a 'watching the world cup – responses may be delayed" signature at the bottom of my work email?" asks Nate Phillips.
Please note that, due to an overwhelming number of inquiries, our responses may be delayed.
It was possible that the pattern of responses to M45 would be affected by the immunoproteasome in a temporal fashion (i.e. responses may be delayed rather than absent).
Since responses may be delayed, evaluation of best response will lead to a higher response rate as compared to response evaluation after two cycles.
Cytokine responses may be delayed for minutes or hours relative to ANS and HPA responses, because cytokines are produced by activated lymphocytes and macrophages [ 97- 99].
In conclusion, some patients with high-grade glioma may stabilise or respond to a treatment with TMZ, which should be administered >two cycles (unless significant deterioration) since responses may be delayed.
The neurological examination remains the gold standard; however, motor responses may be delayed up to 5 days in patients undergoing TH and neurological examination is not sufficient to accurately predict prognosis.
Keep in mind that response times may be delayed during student breaks in May, late August, December, and January.
However, analyses of pretreatment tumor biopsies for markers predictive of response, including PD-1 ligand (PD-L1) expression and mutational burden, are insufficiently precise to guide treatment selection, and clinical radiographic evidence of response on therapy may be delayed, leading to some patients receiving potentially ineffective but toxic therapy.
