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Martins-de-Souza, D. et al. Plasma fibrinogen: now also an antidepressant response marker?
Consistently, our analysis of the highly sensitive auxin response marker pDR5revV2 YFP revealed a moderate auxin response in PXY-positive stem cells and a higher response in differentiated vascular tissues.
In Arabidopsis stems, the activity of the common auxin response marker pDR5rev GFP30 was detected in vascular tissues (phloem and xylem) and cortical cells prior and during cambium initiation (Fig. 1a, Supplementary Fig. 1a 23.
We sought a method for any reader to quantify the limit, imposed by variability, to sustainably observable R2 between any baseline predictor and response marker.
We sought to determine the association between tumor responses in vitro to platinum therapy by using the ChemoFx drug response marker and overall survival (OS) after first-line platinum-based chemotherapy in patients with advanced-stage primary ovarian cancer (POC).
Using data from a recent HIV vaccine efficacy trial, we show that the proposed methodology obtains efficient inference on a parameter defined as the overall risk of HIV infection in the vaccine arm of an efficacy trial, under arbitrary posited shifts of the distribution of an immune response marker away from its observed distribution in the efficacy trial.
The CTC count, as determined by the CellSearch System (Janssen Diagnostics LLC, Raritan, NJ), is a strong, independent prognostic factor for overall survival in patients with mCRPC at various time points during treatment and, as an early response marker, outperforms traditional response evaluations using serum prostate specific antigen (PSA) levels, scintigraphy as well as radiography.
Our results, however, suggest that [18F]FLT uptake changes as a response marker can be observed regardless of change in perfusion.
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Due to the associated side effects and high costs, therapy response markers have been thoroughly sought.
The blockbuster model, the salvation of big pharma in years past, is further threatened by continuing advances in genomics and the discovery of drug response markers.
To evaluate whether pretreatment dehydroepiandrosterone (DHEA) supplementation improves ovarian response markers, ovarian response to standard low-dose gonadotropin stimulation, and in vitro fertilization (IVF) outcomes in poor responders.
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