This in turn could trigger a cell stress response, one manifestation of which is upregulation of heat shock proteins [15].
Some SNPs may lead to multiple and diverse downstream effects, e.g. altered transcriptional response and manifestation of disease (Sakuntabhai et al., 2005).
One of the early events in liver carcinogenesis is p53 overexpression, which has been detected in nodules of non-tumourous liver cirrhosis and which is considered to indicate a cellular stress response preceding manifestation of HCC (Livni et al, 1995).
Owing to an inadequately immune response, clinical manifestations of SBP in cirrhotic patients may be atypical.
Observational studies on drugs are particularly susceptible to the concerns of reverse causation and confounding-by-indication. Reverse causation defines the causality bias if the exposure is a response to manifestations of the undiagnosed disease.
The subsequent proinflammatory responses are manifestations of the innate immunity and usual landmarks of infection and septic syndromes.
For a full response to the manifestation argument, see Miller 2002.
A more direct realist response to the Manifestation challenge points to the prevalence in our linguistic practices of realist-inspired beliefs to which we give expression in what we say and do.
These data suggest that timely control of the destructive immune response after disease manifestation could allow spontaneous regeneration of sufficient β-cell mass to restore normal glucose homeostasis.
Latency of analgesic response characterized by manifestation of signs of acute discomfort, e.g., licking of a hind limb or jumping was observed.
