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A detailed study considering the highly-heterogeneous viscoelastic structure, which corresponds to a seismic velocity anomaly, and/or multiple causalities, in addition to the viscoelastic response, is indispensable for understanding the overall postseismic process in the study area, leading to an understanding of island arc deformation in subduction zones.
Therefore a better understanding of how molecular markers are associated with therapeutic response is indispensable in selecting the correct drugs for treatment.
This type of response is indispensable in maintenance of genome integrity and thus ubiquitous across different cell types as well as different taxa.
Thus, a better understanding of helminth-induced regulation in the antimalarial response is indispensable for the rational development of effective antimalarial vaccines and novel therapies to alleviate or prevent the symptoms of severe malaria.
Our results provide in vivo evidence that stress-induced autophagic response is indispensable for resolving premature senescence in duct cells of the ligated glands, whereas ATG5 deficiency leads to delayed acinar cell death.
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This recent work suggests that anti-commensal effector pTH17 and memory TH1 CD4+ T-cell responses are indispensable for optimal anticancer effects as mediated by cyclophosphamide.
This is particularly important in disease settings, because dysregulation of adaptive immune response is considered indispensable in the pathogenesis of autoimmune rheumatic diseases [ 83]; in many studies, altered expression of miRNAs in PBMCs or diseased tissue with leukocyte infiltration, instead of purified innate immune cells, was observed.
Most immune assays aim to gauge M.tb responses measure IFN-γ, which is indispensable to contain M.tb, yet other immune effector cytokines, e.g. IL-17, may also be instrumental in immune protection.
In MyD88-deficient mice, the production of inflammatory cytokines such as tumor necrosis factor-α, IL-1β and IL-6, the proliferation of B cells, and the induction of endotoxin shock in response to LPS (TLR4 ligand) are also completely abolished, demonstrating that MyD88 is indispensable for the responses to LPS in vivo [ 26].
However, creating a schedule to ration capacity and energy is indispensable for sustaining response efforts over the days and weeks required.
To conclude, although successful deliberation itself is demanding (e.g. Ryfe, 2005), deliberative design of SPIs is indispensable especially in response to wicked problems where simple all-embracing and uncontroversial solution pathways do not exist (Dietz, 2013).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com