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In the past decade, cancer immunotherapy studies have extensively focused on the attempt to exploit the highly specific nature of the adaptive immune response for the development of novel treatments.
While our results highlight that the primary cellular response is an anti-proliferative response (as opposed to an apoptotic response), for the development of ETP-45658 as a potential therapeutic, we questioned if ETP-45658 exposure was associated with any degree of toxicity, one of the most fundamental questions for any proposed therapeutic.
Furthermore, as there is a complete lack of information regarding the detailed immune response against hTERT from studies using full-length hTERT mRNA for vaccination [ 7], it was important to identify hTERT epitopes potentially relevant in the antitumour response for the development of the next generation of hTERT vaccines.
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Growing knowledge of the complex mechanism strongly suggests the need for combining different approaches to various immune responses for the development of a more effective cancer immunotherapy.
The rarity of post-histoplasmosis fibrosing mediastinitis (PHFM) in areas where H. capsulatum is endemic suggests that an abnormal immunological host response may be responsible for the development of fibrosis.
Surgery itself also incurs an inflammatory response which may be responsible for the development of arrhythmias.
To improve the clinical response for cancers, the development of CART cells for CSCs is imperative.
The simulations explicitly account for microstructure, constituent properties, and interfacial responses and capture processes responsible for the development of hotspots and damage.
Accomplishment of the MDGs with respect to women's empowerment is closely connected to the implementation of the IASC (2006) guidelines that are not only important for disaster response, but for the development of underprivileged women, who continue to live in poverty.
However, only recently has this process and the significance of monocyte proinflammatory response heterogeneity for the development of ALI been appreciated.
More insight into the pharmacokinetics and intracellular metabolism of 5-FU in tumour tissue is essential for a better understanding of the variability of patient response and for the development of improved therapy protocols.
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