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Dissection of the underlying molecular events responsible for the observed differences in viral replication and immune response could provide a better understanding of the swine immune system and the host factors responsible for PCVAD susceptibility.
Inducing this local immune response could provide a great opportunity for controlling intestinal intracellular pathogens in neonates, as we have previously reported for cryptosporidiosis [14].
Given the requirement of IFNγ for bacterial clearance and the fact that NK cell involvement in the innate response could provide an initial burst of IFNγ, we cultured these primary DCs in the presence of IFNγ.
We further observed that L. donovani is more sensitive to UPR inducing agents than host macrophages, suggesting that the less evolved stress response could provide a new avenue for therapeutic treatment of parasitic infections.
The temperature response could provide a mechanism by which the central clock can synchronize cartilage rhythms.
Future investigation into these regulators of the inflammatory response could provide a clearer picture of the complex interactions involved that lead from excessive inflammation to disease progression.
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Our ability to precisely modify both innate and adaptive immune responses could provide new therapeutic directions in a variety of diseases.
Further, the ability of PMED DNA vaccines to induce mucosal immune responses could provide additional benefit by limiting viral replication at the site of exposure.
In these patients, perhaps the well-described influence of the underlying acute illnesses (pulmonary contusion and intracranial hemorrhage) on host immune responses could provide part of the explanation [30], [31].
Genetic variation in strigolactone responses could provide an opportunity to breed plants with superior nutrient use efficiency and ability to form symbiotic associations.
Thus, identifying genetic variation associated with variation in phenotypic responses, could provide valuable insight into the genetic basis of drought adaptation.
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