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NAb response breadth was measured 5 years after infection against five subtype A viruses and one subtype B virus.
We examined correlates of NAb response breadth among 70 HIV-infected, antiretroviral-naïve Kenyan women from a longitudinal seroincident cohort.
Greater NAb response breadth was associated with a higher viral load set point and greater HIV-1 env diversity early in infection.
However, greater NAb response breadth was not associated with a delayed time to a CD4 T-cell count of <200, antiretroviral therapy, or death.
Interestingly, mice primed with full-length gag and boosted with DNA vaccine fragments induced similar T-cell response breadth as mice both primed and boosted by fragments DNA.
Thus, a broad NAb response results from a high level of antigenic stimulation early in infection, which likely accounts for prior observations that greater NAb response breadth is associated with a higher viral load later in infection.
Similar(48)
In reviewing John Cassidy's analyses of the year's events, what stands out is the responses' breadth — not just thematic, but temporal.
Thus, if a single protein length peptide set is used, consensus or COT peptides are optimal for detecting responses, yet the breadth of T cell responses is extended with the use of coverage-optimized peptides.
According to Trenchard, several factors inform this analysis, including the importance of the issues at stake and an examination of the proportionality of the party's response given the breadth of the case and the ESI being reviewed.
The magnitude, response rate and breadth of HIV-1 specific T-cell responses in each group and the possible impact of pre-existing Ad5 antibodies on these responses were assessed using an IFN-γ ELISPOT assay.
Considering these findings and our own, there is emerging support for an association between Gag-specific CD8+ T-cell response magnitude and/or breadth, and clinical parameters such as viral load and blood CD4 count.
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