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Additionally, all three subjects completing week 120 had a good and sustained response achieving PedACR90.
Importantly we found that one-fifth of responding patients had a delayed response, achieving stable disease at their end of treatment scan but partial response during subsequent follow-up while off treatment.
Four patients (10%), showing a ⩾50% PSA decrease with docetaxel plus estramustine treatment, improved their response achieving a PSA decrease ⩾90% during mitoxantrone/prednisone; no patients with PSA stabilisation during docetaxel/estramustine improved response with the second part of the treatment.
All three subgroups experienced improvements from baseline in both TJC and SJC at all time points measured, with those who reported intolerance to IFX or loss of response achieving a slightly greater benefit compared with those who had no response to IFX (Table 3).
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Table 2 shows the Box Behnken design of experiment and response achieved.
The greater immune response achieved by high expression was maintained over a 100-fold dose range.
The response achieved by the bridges with the aspect ratio of 1.1 was consistently larger compared to the lower aspect ratios.
The major pathologic response achieved with alectinib may warrant clinical trials of alectinib in postoperative adjuvant treatment for resectable ALK-rearranged NSCLC patients.
"Best response" was defined as the response achieved when one or more additional cycles of chemotherapy were given and no additional tumor shrinkage was noted.
The best clinical response achieved was s.d.
The most common reason for early withdrawal in the randomised groups was disease progression (ie, response achieved, then loss of response; or insufficient response achieved; or response achieved but disease flared).
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com