A number of studies have provided evidence that estrogens have a role in all phases of wound healing by modifying the inflammatory response, accelerating re-epithelialisation, stimulating granulation tissue formation and regulating proteolysis.
We have also demonstrated that the local form of IGF-I (mIGF-I) promotes an increased recruitment of proliferating bone marrow cells to injured transgenic muscles and modulates the inflammatory response, accelerating the functional rescue of injured skeletal muscle (Musarò et al. 2004; Pelosi et al. 2007).
With news reports highlighting this figure, investors were forced to consider the possibility that inflation might start picking up, and that the Federal Reserve might, in response, accelerate its interest-rate hikes — something that had been ruled out in the Goldilocks scenario.
Similarly, we showed in a model of atherosclerosis and surviving sepsis that persistent local and systemic inflammatory response accelerated atheroma burden in mice despite the fact that they appeared clinically normal [7].
However, the response accelerates when light depolarizes the photoreceptor.
Early-life immune response accelerated ageing, as shown by a reduction in maximum lifespan.
It is also possible that the declines in undernutrition observed started prior to the earthquake and that the earthquake response accelerated that decline.
Faist and coworkers [ 14] proposed a two-hit hypothesis in which NIs represent a second insult to a previously injured and primed host, converting a low-grade or regulated host response into an accelerated or dysregulated host response (accelerated systemic inflammatory response syndrome), triggering new or progressive organ dysfunction.
Chronic hyperglycemia and concomitant increase in free fatty acids and other lipid metabolites are associated with glucolipotoxicity, which further emphasizes insulin resistance and β-cell failure (by causing dedifferentiation of pancreatic β-cells, activation of stress response, accelerated apoptosis, and decreased proliferation) (2).
Schistosome infection is controlled by treatment of infected people with the anti-helminth drug praziquantel and we have previously shown that treating S. haematobium infection alters schistosome specific humoral and cellular responses, accelerating the development of these responses [ 9, 10].
If they are developed, validated signatures for AD will enable a rapid identification of prodromal AD patients and could potentially enable the evaluation of drug responses, accelerating the whole process of drug development [ 2- 4, 6- 8].
