A very interesting result in this study was the priming of the cellular immune response by a single dose of vaccine in the absence of a measurable antibody response.
At 1 month following the first dose in those aged 60 64 years (mean age, 62 years), the response to a single dose of PCV13 was at least as good as the response to PPSV23 for all of the serotypes (noninferior) and statistically significantly higher for 9 of the 13 serotypes.
In additional immunogenicity experiments neither the magnitude of the response to a single dose of vaccine, nor the estimation of the dose necessary to induce a measurable response were able to consistently detect brief exposure of vaccines to potentially damaging temperatures.
During analysis of the dose dependent transcriptional response to MMS and γ-ray, we sought to identify genes whose transcription was only modulated in response to a single dose of damaging agent.
The latest trials, done in about 600 children and teenagers, ages 10 to 17, found that they received a "robust immune response" from a single dose, Dr. Fauci said.
Our second aim was to evaluate the therapy response after a single dose application of this agent.
Complementary studies are in progress to bridge our findings to other populations, and to further document the long-term durability of antibody response following a single dose.
In fact, the cross-immunity described here could explain, at least in part, the strong immunological response to a single dose of pandemic A/H1N1 vaccine in adults.
There are three published studies and there is one set of preliminary data on the humoral response to a single dose of 2009 pandemic influenza A(H1N1) vaccine in comparable groups of HIV-infected patients (Table 4) [11]–[14].
Rhythms in response to a single dose of deltamethrin have previously been observed in pine weevil, Hylobius abietis [5]; differences between species are possibly due to the substrate specificity of XM genes within each species.
