LRC, local-regional control; LVI, lymphovascular invasion; pCR, pathologic complete response A multivariate analysis was performed that included constructed subtype, clinical stage, grade, presence or absence of LVI, pCR versus no pCR and number of positive lymph nodes dichotomized as zero to three versus four or more.
In the French Orencia and Rheumatoid Arthritis (ORA) registry, positivity for anti-cyclic citrullinated peptide (CCP) antibodies was associated with European League Against Rheumatism (EULAR) response in a multivariate analysis, after adjustment for Disease Activity Score (DAS 28 [ 11].
Alternatively, one may use both traits as response variables in a multivariate analysis of variance (manova), an approach that has only recently been applied in a parasite trade-off context (Vale et al. 2011; see also Mideo et al. 2011).
For example, a large scale cohort study conducted in Zambia and Rwanda, involving 933 HIV-infected and 388 HIV-uninfected patients, demonstrated that HIV infection did not impact the likelihood of serologic response to therapy in a multivariate analysis (OR, 1.001; P = .995) [ 15].
The cPLA2 α was also an independent prognostic marker of poor response to endocrine therapy in a multivariate analysis that also included hormonal treatment, ER and HER2 expression to adjust for any bias because of the association of cPLA2 α expression with ER negativity (which itself correlates with endocrine resistance).
The variables proving significant in univariate analysis were included in a multivariate analysis: favorable response and 100-day survival were assessed by a stepwise logistical regression analysis, whilst OS was determined by a Cox regression analysis.
Using the Cox model adjusted according to age at diagnosis for a multivariate analysis, pathological response to primary chemotherapy and survivin overexpression remained the only parameters with a significant impact on prognosis in our series of breast cancer patients; no other association with overall survival was observed for the remaining variables (Table 4).
In a multivariate analysis (Cox) of response duration, only NSE and type of response had significant influence.
In the study mentioned above, a multivariate analysis showed that response to lenalidomide therapy was negatively affected by the presence of thrombocytopenia and increased transfusion requirements.
A multivariate analysis based on principal response curves indicated that communities in streams exposed to 222 419 mg/L were significantly different from the controls leading to an overall (multivariate and univariate) conclusion that 0.106 mg/L was the ecosystem NOEC.
A multivariate analysis was performed for survival, based on responses to the first episode of chemoembolisation.
