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In patients with assessable tumour response, a higher TTP was observed in those who achieved a complete or partial response (11 months) than in those with stable disease (10 months) or progressive disease (2.7 months; P<0.001) after FOLFIRI treatment.
The degree of TIL distribution changes exerted by chemotherapy was related to pathological response: a higher (over the median) chemotherapy-induced decrease of the total infiltration by T cells (CD3) was significantly related to pCR even after adjusting for tumor subtype in the multivariate analysis (P = 0.001; OR = 17.84, 95% CI 3.02 to 105.27).
Further, in a small series of 57 breast cancer patients treated with trastuzumab-based therapies, high amounts of pSrc-Y416 in tumours correlated with lower clinical response, a higher progressive disease and shorter overall survival rates than patients having low active Src tumours.
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Ms. Laybourne's response, a high-risk 24-hour cable venture called Oxygen, will make its debut on Feb. 2 in a half-dozen major cities and suburban areas (but not New York and parts of Los Angeles).
When looking at an individuals' immune response, a high inter-individual variance and highly dynamic changes can be observed over time (Figs. 1 and 2) [4].
One very important difference between a system step response and a higher order response is that a step response is bounded, while a higher order response is not.
Effective calls were also characterized by more-quantitative responses (a higher ratio of numbers to words) and fewer of the big-picture words (such as growth, strategy, and reputation) that are typical in the vocabulary of CEOs.
Inflammation is also part of the immune response, and a higher rate of infections is a troublesome side effect.
After a number of years, supply may increase in response to a higher level of demand reflected by higher prices.
Defence Minister Ehud Barak said that "additional shelling into Israel from Syria will elicit a tougher response, exacting a higher price from Syria".
This response indicates a higher sensitivity to ionizing radiation.
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