Previously, we reported that ∼2.8% of the 5-month-old, newly incorporated neurons responded to exploration [2].
Based on calculations using the current data and that obtained previously [2], we hypothesize that new neurons may no longer respond to spatial exploration after they are 301 days old, and that in a 7-month-old animal the majority (60%) of the neurons that respond to exploration were born during adulthood.
This will allow us to determine if a linear model is adequate and will test the prediction that cells no longer respond to exploration after they are ∼1 year old.
No differences were found in layer 3. Here, we found that the proportion of new granular cells that responded to exploration 30 days after these neurons were born was 5%, and at day 45 PBI it was 4.8%.
The enhanced plasticity of newly incorporated neurons (4 to 6 weeks of age) was confirmed in the present study with the observation that ∼5% of the new neurons found at 30 45 days PBI responded to exploration by expressing Arc, whereas only 1.5% of the total DG neurons responded.
The model also suggests that in a 7-month-old animal, 60% ([5-month-old and 99%] if we include all neurons added postnatally) of the total granular neurons that responded to exploration should be neurons born after the DG was fully formed.
If we include in our calculation all the neurons born after the animal's birth that survive for 30 days, the result suggest that at day 129 of the animal's life, 99% of the neurons that respond to exploration are neurons that were born post-natally (Figure 5D, shaded line).
A new government in Greenland is now seeking to slow the pace of exploration, responding to concerns about drilling's impact on the environment and indigenous lifestyles.
Human resources for health illustrates how responding to one issue requires exploration of other aspects of the health system.
This suggests that the likelihood of a new neuron to respond to behavioral exploration decreases with time [28].
From this population of neurons, 1.5% (3,465) responded to spatial exploration, a result similar to what has been reported previously [22], [26], [27].
