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As a consequence of this slower proliferation, these tumours respond in a similar manner to late-responding normal tissue rather than early responding normal tissue [13 15], thereby removing the rationale for hyperfractionated schedules.
As the dose per fraction increases, the probability of toxic effects in late-responding normal tissues increases disproportionately compared with early responding normal tissues, which are typically less sensitive to fractionation [4].
Hence, typically, late-responding normal tissues have a smaller α/β ratio (about 2 Gy) than either tumour tissue or early responding normal tissues (about 10 Gy) [7].
Late-responding normal tissue toxicity can be further subcategorised into primary effects due to apoptosis of slowly proliferating cells and consequential effects due to initially acute damage of early responding normal tissue.
The biologically effective doses (BED) were calculated assuming 4 Gy α/β ratio (tumour control), 10 Gy (acute responding normal tissues) [ 9].
The α/ β ratio is a measure of fractionation response, with low ratios (high α/ β's) associated with late responding normal tissues.
Similar(47)
This raises the possibility that subjects, who are resistant to the effects of insulin on glucose uptake, may respond normal to the effects of exercise on glucose uptake.
The present study was designed to determine if rates of responding for normal food were sensitive to the effects of cannabinoid receptor blockade.
Exclude European marijuana, much of which is domestically produced.It may seem distasteful to think of drugs as a business, responding to normal economic signals.
If the normal tissue and the tumour exhibit similar sensitivity, there is no therapeutic window, and at drug concentrations at which the tumour responds, normal tissue is damaged.
Secondly, to investigate whether parents change their speech when it is directed to their CI child as opposed to their NH child and how adept the CI child is at responding in normal-domestic and noisy backgrounds.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com