For comparisons between non-responders and responders the same tests were used.
The consensus matrix also indicates one patient (1 126 381) which is labeled as a good responder, but grouped together with the bad responders (the same patient is also misclassified in the HMMConst2 as indicated in the Supplementary Material).
Due to the fact that central necrosis is often seen in responders, the same authors incorporated this in morphology, attenuation, size and structure (MASS) criteria, and found that the assessment of mRCC target lesions on contrast-enhanced CT is more accurate using MASS criteria than SACT criteria, modified Choi criteria and RECIST criteria.
Plasma level of nilotinib will be compared between responders and non-responders in the same manner.
It is important to note that both responders and non-responders reported the same initial improvement in all MacNew and EQ-5D HRQL scale scores after CR (global: p =.622; physical: p =.948; emotional: p =.377; social: p =.711, mobility; p =.784; self-care: p =.881; daily activities: p =.451; pain: p =.655; anxiety/depression: p =.293).
In the placebo group, 18 responders and two non-responders continued the same treatment and 17 of these were classified as responders at the end of treatment.
Using the questionnaires on the other hand, each responder received the same set of questions phrased in exactly the same way, so the answers were derived in a more objective way.
As such, we do not know if the characteristics of the non-responders are the same as the responders.
It has been asserted that late responders have the same characteristics as non-responders in population surveys [ 49].
Interestingly, like the protozoa, and the GSR to repetitive shock, individually examined subjects divided into habituaters (high initial responders) and sensitizers (low initial responders) to the same eight repetitive tone stimuli in each of the four effector systems examined (Fig. 1).
