To further test competing hypotheses, we asked how weight sets included in valid hypotheses would respond to defined perturbations that correspond to feasible manipulations of the experimental system under investigation.
In contrast, metabolic and steroid measurements made after long-term culture reflect the inherent capacity of GC to adapt and respond to defined glucose and insulin environments in vitro.
In addition, technologies for genetically engineering novel immune receptors, termed chimeric antigen receptors (CAR), enable programming T cells to respond to defined ligands, and this approach has recently demonstrated great promise for cancer immunotherapy in both preclinical and clinical investigations.
This sensor responded to defined perturbations of the BMP-Smad pathway (Supplementary Figure 7), indicating that it serves as reliable readout for endogenous signaling.
In the strategy used here, changing the promoter driving HcRed expression and reconstituting mice lacking a specific hematopoietic cell by injecting gene-modified Pax5−/− pro-B cells, allows the identification and cell fate tracing of those reconstituted cells responding to defined stimuli.
By measuring large numbers of animals responding to defined random patterns of optogenetic stimulation, we were able to collect enough data to use reverse-correlation analysis to connect optogenetic activation patterns of sensory neurons with motor patterns (Ringach and Shapley, 2004).
Of course, great art will doubtless emerge that does directly respond to the defining events of our anxiety-filled age.
Epithelial structures are generated when groups of cells respond to signals defining their fate and organization.
The way people respond to change defines their destinies.
Over the past twenty-five years, the explosion in molecular biology, genomics, and proteomics has produced enormously powerful tools for unraveling the molecular cascades that interface with and respond to environmental (defined broadly) demands.
