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Microsporidial infections in HIV-infected individuals may respond to combination of antibiotics and antiparasitic agents, including topical propamidine isethionate, topical fumagillin, topical fluoroquinolones, oral albendazole, and/or oral itraconazole.
Aggressive metastasizing GCT may arise in the uterus, and may respond to combination chemotherapy.
Some anaplastic oligodendrogliomas respond to combination chemotherapy [ 2, 3], and better progression free survival and chemo-responsiveness appear to be linked to the presence of these deletions [ 4, 34].
In addition, predictive markers of response would be invaluable in individualising patient treatment as it would enable discrimination of those patients likely to respond to combination therapy from those likely to be non-responsive.
Patients infected with GT 1 who carry a genetic variant allele near IL28B gene are more likely to respond to combination therapy (pegylated interferon-alpha-2a or -2b and ribavirin) [ 14] and clear spontaneously [ 15].
Analysis of the metabolic profiles of serum collected from metastatic breast cancer patients assisted in identifying a subset of patients that were more likely to respond to combination therapy [95].
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It's possible this gene — or a smorgasbord of other genes — could determine how we respond to combinations of cannabinoids, terpenes, and flavonoids, or why someone like Volodarsky gets sleepy on flower, but amped on dabs.
In other words, it is unlikely that patients will respond to combinations with specific inhibitors unless the intended target is a significant driver of endocrine-resistant growth.
Although many patients initially respond to combinations of cytoreductive surgery and platinum/taxane chemotherapy, most patients experience subsequent recurrences (International Collaborative Ovarian Neoplasm Group, 2002; du Bois et al, 2003).
Our findings that KRASM cancers could respond to combinations of MEK + AKT inhibitors is interesting and other groups have shown MEK + AKT inhibitors could be effective in cells with mutations both in KRAS and PIK3CA [ 24].
Patients who responded to combination therapy had increased CD8+ T cells, elevated PD-L1 protein expression, as well as IFN-γ gene expression on several cell subsets in tumors after talimogene laherparepvec treatment.
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