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But these side effects almost always respond to appropriate adjustments in doses.
Many patients develop uncomplicated resolving infections that respond to appropriate antimicrobial therapy while others develop persistent or complicated infection with metastatic foci (e.g. infective endocarditis (IE)), which may be fatal.
However, many children who have suggestive clinical signs of pneumonia and who respond to appropriate antibiotics do not have any abnormalities on the chest radiograph taken at the onset of the illness; furthermore, radiological facilities are not always available in developing countries.
Pelvic vein occlusion should be suspected in patients with abdominal pain, a unilateral pelvic mass, uterine infection and fever that fails to respond to appropriate treatment [70].
Most patients suffering from low back pain improve satisfactorily without surgery, but 1 5% of them do not respond to appropriate nonsurgical care, such as muscle strengthening, physical therapy, massage, manipulation, weight control and analgesia, and may be candidates for surgical treatment [1, 2].
The rationale for a differentiation therapy is based on the assumption that cancer cells have retained the potential to respond to appropriate differentiation signals, which in turn would be sufficient to restore a normal phenotype.
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Medication withdrawal is strongly recommended and its use can be viewed as a "reset" that then affords patients a greater likelihood of positively responding to appropriate prophylactics [13, 17, 18].
Preemptive therapy for colonized patients or those with high-risk scores and empirical therapy in septic patients not responding to appropriate antibacterial treatment are possible early interventions (Figure 2) [28, 60].
Case 1: deliberate methanol ingestion, presenting 24 hours after ingestion and not responding to appropriate medical management.
In 22 cases (37%), patients experienced moderate/severe mucocutaneous toxicity as a consequence of 5FU, which responded to appropriate dose modifications.
Importantly, this indicates that the network organisation, seen in the spatial architecture revealed here, is in place and readily responds to appropriate signals.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com