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She had failed to respond to adequate trials with various antipsychotics, alone or in combination with carbamazepine.
Background: The treatment of schizophrenic patients who fail to respond to adequate trials of neuroleptic drugs is a major challenge.
The consensus statement of the European Headache Federation EHFF) defines CM refractory to treatment (rCM) when it does not respond to adequate dosages of at least 3 drugs from the classes of beta-blockers, anticonvulsants, tricyclics, onabotulinum toxin A and others (e.g., flunarizine, candesartan) for at least 3 months each, in absence of medication overuse[3].
Surprisingly, we identified a regulatory feedback loop of two phz gene clusters expression, which involved a small amount of PCA produced from the gene cluster phzA2-G2 that could function as a signaling molecule to induce self-expression and to activate the expression of the phzA1-G1 cluster, and could respond to adequate amounts of synthetic PCA in response to environmental cues.
Weight loss has been shown to respond to adequate glycemic control, and the severe manifestations subsided within 10 months in all cases.
Our study included subjects who had severe CRS (mostly white and black Americans from an urban, academic center) who failed to respond to adequate trials of medical therapy.
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It was conducted in 60 primary care patients with MDD who had not responded to adequate treatment with citalopram.
Septic shock was defined as sepsis-induced hypotension along with the presence of perfusion abnormalities, initially not responding to adequate fluid resuscitation.
Some would ask whether vasopressin infusion could be used as the first agent in patients who have not responded to adequate volume resuscitation, especially since vasopressin was most effective in patients who had less severe septic shock in VASST.
The World Health Organization Collaborating Center consensus proposed that RA patients with active disease who have failed to respond to an adequate course of DMARDs are eligible for anti-cytokine therapy [ 5].
14 When patients fail to respond to an adequate course of antidepressants, current guidelines recommend increasing the dose of the current antidepressant, switching to a different antidepressant, or augmenting treatment with other drugs.
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